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6S Evidence-Based Clinical Resources

This guide is intended to help the busy clinician find the best evidence quickly using a hierarchy of content by levels of evidence.


“The next best step is to look for summaries. These include clinical pathways or textbook summaries…. Evidence-based, current clinical practice guidelines… are also examples of “summary” level evidence.” (DiCenso)

CMA InfoBase: Clinical Practice Guidelines  

  • Database of CPGs developed or endorsed by authoritative medical or health organizations in Canada

DynaMed Plus  

  • Point of care, evidence based clinical summaries on over 3000 topics
  • Monitors over 500 journals & systematic evidence review sources with new evidence integrated daily

First Consult  

  • Continuously updated, evidence-based content aimed at primary care providers
  • Part of Elsevier’s ClinicalKey – change drop-down from “All Types” to “First Consult”


  • Information on drugs and other chemicals to which breastfeeding mothers may be exposed
  • Includes information on possible adverse effects of levels in breast milk and infant blood 
  • Also suggests therapeutic alternatives when appropriate

National Guideline Clearinghouse 

  • A comprehensive, international collection of evidence-based clinical practice guidelines

Natural Medicines (formerly Natural Standard and Natural Medicine Comprehensive Database)  

  • Summarizes & grades (from “strong evidence” through “strong negative evidence”) for foods, herbs, supplements and non-herbal modalities such as acupuncture.
  • Can also be searched for CAM interventions by disease or condition
  • Includes information on drug interactions and contraindications


  • OrthoEvidence is a global orthopaedic-focused evidence-based summary provider built for the orthopaedic community by orthopaedic experts. Their CoreView presents critical topics in musculoskeletal research, highlighting and graphically summarizing evidence from their database of ACE reports.


  • Regularly updated texts to answer clinical questions about patient care, diagnosis and treatment
  • Focuses on internal medicine and subspecialties


  • A diagnostic decision support system designed by clinicians to aid medical professionals in the diagnosis of visually identifiable diseases
  • Includes more than 18,000 images representing over 1,000 diseases, drug reactions, and infections
  • Mobile access requires an internet connection

  Canadian  |   freely available  |   mobile app  |   U of C licensed  


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